Indianapolis Colts vs Buffalo Bills Betting Picks, Predictions Odds & Lines 11/21/2021

Indianapolis Colts vs Buffalo Bills Betting Picks, Predictions Odds & Lines 11/21/2021

It’s now or never for the Indianapolis Colts (5-5 SU, 6-4 ATS) to show against the top dogs after dismantling two uninspiring teams in the Jaguars and Jets over the past two weeks.The Bills (6-3, 5-3-1) will get another chance to prove themselves against the Jets (6-2, 5-2), who were embarrassed in a 48-17 drubbing last Sunday.

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Indianapolis Colts vs Buffalo Bills Betting Odds & Lines

The Bills opened as 7.5-point favorites and are now -7 at BetOnline Sportsbook. The overall has also seen a little movement, starting at 49.5 and gradually climbing to 50.0 points.

Notes On The Indianapolis Colts

The Colts’ next two games will have a big impact on their season, with road trips to face the Bills and Buccaneers. Given that they’ve yet to defeat a team with a winning record this season, their prospects don’t appear good.

Despite a poor pass rush, the Bills’ defense will almost certainly dominate this matchup. Jonathan Taylor will require a performance of that magnitude, as he has in the past.

The question is whether they can play against a winning team and win. Their offense is healthy and the defense needs to improve.


Notes On The Buffalo Bills

The Bills have one of the most feared defenses in the league, and they’ve demonstrated what they’re capable of against top foes. The Bills took advantage of their matchup with the Jets to obtain some much-needed momentum.

This season, Allen has delivered on a weekly basis and has spread the ball out more, which is good news for this offense rather than relying heavily on Stefon Diggs.

Running back is a difficult position. But it has become even more difficult since Matt Breida, who scored two touchdowns last week. Devin Singletary, Zack Moss and Matt Breida will all be used in some way. It may not be the best fantasy situation but it will make Buffalo a tougher team to beat.

Can The Indianapolis Colts Cover The Pointspread?


Indianapolis has given up far too many points to mediocre competition. Facing the Bills’ potent offense will be difficult. A +7 spread appears manageable if the Colts’ defense plays well.

Can The Buffalo Bills Cover The Spread?

The Bills could run up the score against the Colts if Jonathan Taylor is taken out, since Carson Wentz will be unable to handle it without an effective Taylor. Meanwhile, following his destruction of the Jets, Josh Allen appears to be in control. He’ll almost certainly deliver another outstanding performance.

Pick & Prediction: Buffalo Bills -7

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